UV light is found in sunlight and is emitted by electric arcs and specialized lights such as black lights. As an ionizing radiation it can cause chemical reactions, and causes many substances to glow or fluoresce. Most people are aware of the effects of UV through the painful condition of sunburn, but the UV spectrum has many other effects, both beneficial and damaging, on human health.
Damaging effects
Human Skin - Sunburn / Skin Cancer
UVA, UVB and UVC can all damage collagen fibers and thereby accelerate aging of the skin. Both UVA and UVB destroy vitamin A in skin which may cause further damage. In the past, UVA was considered less harmful, but today it is known that it can contribute to skin cancer via indirect DNA damage (free radicals and reactive oxygen species). It penetrates deeply but it does not cause sunburn. UVA does not damage DNA directly like UVB and UVC, but it can generate highly reactive chemical intermediates, such as hydroxyl and oxygen radicals, which in turn can damage DNA. Because it does not cause reddening of the skin (erythema) it cannot be measured in SPF testing. There is no good clinical measurement for blockage of UVA radiation, but it is important that sunscreen block both UVA and UVB. Some scientists blame the absence of UVA filters in sunscreens for the higher melanoma-risk that was found for sunscreen users.
UVB light can cause direct DNA damage. The radiation excites DNA molecules in skin cells, causing aberrant covalent bonds to form between adjacent cytosine bases, producing a dimer. When DNA polymerase comes along to replicate this strand of DNA, it reads the dimer as "AA" and not the original "CC". This causes the DNA replication mechanism to add a "TT" on the growing strand. This is a mutation, which can result in cancerous growths and is known as a "classical C-T mutation". The mutations that are caused by the direct DNA damage carry a UV signature mutation that is commonly seen in skin cancers. The mutagenicity of UV radiation can be easily observed in bacteria cultures. This cancer connection is one reason for concern about ozone depletion and the ozone hole. UVB causes some damage to collagen but at a very much slower rate than UVA.
As a defense against UV radiation, the amount of the brown pigment melanin in the skin increases when exposed to moderate (depending on skin type) levels of radiation; this is commonly known as a sun tan. The purpose of melanin is to absorb UV radiation and dissipate the energy as harmless heat, blocking the UV from damaging skin tissue. UVA gives a quick tan that lasts for days by oxidizing melanin that was already present and triggers the release of the melanin from melanocytes. UVB yields a tan that takes roughly 2 days to develop because it stimulates the body to produce more melanin. The photochemical properties of melanin make it an excellent photoprotectant. Older and more widespread sunscreen chemicals can not dissipate the energy of the excited state as efficiently as melanin and therefore the penetration of these sunscreen ingredients into the lower layers of the skin may increase the amount of free radicals and reactive oxygen species (ROS). In recent years, improved filtering substances have come into use in commercial sunscreen lotions that don't significantly degrade or lose their capacity to protect the skin as the exposure time increases (photostable substances).
Sunscreen prevents the direct DNA damage which causes sunburn. Most of these products contain an SPF rating to show how well they block UVB rays. The SPF rating, however, offers no data about UVA protection. In the US, the Food and Drug Administration is considering adding a star rating system to show UVA protection. A similar system is already used in some European countries.
Some sunscreen lotions now include compounds such as titanium dioxide which helps protect against UVA rays. Other UVA blocking compounds found in sunscreen include zinc oxide and avobenzone. Cantaloupe extract, rich in the compound superoxide dismutase (SOD), can be bound with gliadin to form glisodin, an orally-effective protectant against UVB radiation. There are also naturally occurring compounds found in rainforest plants that have been known to protect the skin from UV radiation damage, such as the fern Phlebodium aureum.
Eye
High intensities of UVB light are hazardous to the eyes, and exposure can cause welder's flash (photokeratitis or arc eye) and may lead to cataracts, pterygium, and pinguecula formation.
UV light is absorbed by molecules known as chromophores, which are present in the eye cells and tissues. Chromophores absorb light energy from the various wavelengths at different rates - a pattern known as absorption spectrum. If too much UV light is absorbed, eye structures such as the cornea, the lens and the retina can be damaged.
Protective eyewear is beneficial to those who are working with or those who might be exposed to ultraviolet radiation, particularly short wave UV. Given that light may reach the eye from the sides, full coverage eye protection is usually warranted if there is an increased risk of exposure, as in high altitude mountaineering. Mountaineers are exposed to higher than ordinary levels of UV radiation, both because there is less atmospheric filtering and because of reflection from snow and ice.
Ordinary, untreated eyeglasses give some protection. Most plastic lenses give more protection than glass lenses, because, as noted above, glass is transparent to UVA and the common acrylic plastic used for lenses is less so. Some plastic lens materials, such as polycarbonate, inherently block most UV. There are protective treatments available for eyeglass lenses that need it which will give better protection. But even a treatment that completely blocks UV will not protect the eye from light that arrives around the lens.
Beneficial effects
Vitamin D
UVB exposure induces the production of vitamin D in the skin. The majority of positive health effects relate to this vitamin which has regulatory roles in calcium metabolism (which is vital for normal functioning of the nervous system, as well as for bone growth and maintenance of bone density) immunity, cell proliferation, insulin secretion and blood pressure.
Aesthetics
Too little UVB radiation leads to a lack of Vitamin D. Too much UVB radiation leads to direct DNA damages, sunburn, and skin cancer. An appropriate amount of UVB (which varies according to skin color) leads to a limited amount of direct DNA damage. This is recognized and repaired by the body. Then the melanin production is increased which leads to a long lasting tan. This tan occurs with a 2-day lag phase after irradiation, but it is much less harmful and is longer lasting than the one obtained from UVA.
Medical applications
Ultraviolet radiation has other medical applications, in the treatment of skin conditions such as psoriasis and vitiligo. UVA radiation has been much used in conjunction with psoralens (PUVA treatment) for psoriasis, although this treatment is less used now because the combination produces dramatic increases in skin cancer, and because treatment with UVB radiation by itself is more effective. In cases of psoriasis and vitiligo, UV light with wavelength of 311 nm is most effective.
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